This kaleidoscopic book documents the 3rd Istanbul Design Biennial curated by Beatriz Colomina and Mark Wigley in the words of the curators and all the participants, starting with the polemical Biennial Manifesto that launched the project. A remarkable galaxy of designers, architects, artists, historians, theorists, film makers, archaeologists, choreographers, scientists, labs, institutes, and NGOs challenge the self-image of our species. Are We Human? is an urgent question when design has gone viral, infusing every dimension of human and non-human life. Design now encrusts the whole Earth as a living geological layer going deep into the ground, into outer space, bodies, brains, and genes. This book dramatically rethinks design in the face of a planet and a species in unprecedented crisis rebooting the conversation on design.